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KMID : 0367419940370091317
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Journal of Korean Pediatric Society
1994 Volume.37 No. 9 p.1317 ~ p.1324
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A Case of Cerebral Infarction due to Thrombosis Associated with Focal Segmental Glomerulosclerosis and Steroid Resistant Nephrotic Syndrome
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Abstract
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Focal segmental glomerulosclerosis is the renal histopathologic lesion observed in 10% of children with idiopathic nephrotic syndrome. Complications include infection, thrombosis, hypocalcemia and adverse effect of steroid use. The incidence of
thrombosis reported ranges from 10∼40%. The pathogenesis are changes in coagulation system, decrease of Antithrombin Ⅲ, increase platelet aggregability and steroid or diuretics use. These changes take place passively as a result of increased
protein
synthesis and urinary loss of low molecular weight protein.
We experienced a case of cerebral infarction due to thrombosis associated with focal segmental glomerulosclerosis and steroid resistant nephrotic syndrome in a 11 year old male patient who had been hospitalized because of convulsion and semicoma.
MRI
showed an evolving infarct in the occipital lobe, decreased antithrombin Ⅲ and increased factor Ⅷ on coagulation factor assay.
We hereby report a case of cerebral infarction due to thrombosis associated with focal segmental glomerulosclerosis and steroid resistant nephrotic syndrome with a brief review of related literature
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